Value
To identify high-affinity, functional, and developable fully human antibody leads for any target within 2 months
Description
OmniMab antibody library is developed by APBio. Peripheral blood mononuclear cells (PBMCs) from healthy donors are collected for B cell isolation, and antibody heavy and light chain fragments are cloned using molecular biology. These fragments are then integrated into an optimized phage display vector to create the OmniMab antibody library. For highly promising targets, the library allows the selection of antibody fragments with high affinity through multiple rounds of specific binding and non-specific washing. This selection can be performed using recombinant proteins or cells expressing the target of interest. Subsequently, the antibody fragments undergo genetic sequencing and cloning into an antibody expression vector. Antibody production and purification are conducted in mammalian cells to identify functional antibody candidates by different cell-based assay.
Features
1. Complete ownership of intellectual property
2. Rapid and robust screening for any antigens
3. Provide antibody leads with high-affinity antibodies and diverse functionality
